Human skin organ culture for assessment of chemically induced skin damage
نویسندگان
چکیده
منابع مشابه
Replication of varicella-zoster virus in human skin organ culture.
Varicella-zoster virus (VZV) infection is restricted to humans, which hinders studies of its pathogenesis in rodent models of disease. To facilitate the study of VZV skin tropism, we developed an ex vivo system using human fetal skin organ culture (SOC). VZV replication was analyzed by plaque assay, transmission electron microscopy, and histology. The yield of infectious VZV from SOC increased ...
متن کاملUV-induced skin damage.
Solar radiation induces acute and chronic reactions in human and animal skin. Chronic repeated exposures are the primary cause of benign and malignant skin tumors, including malignant melanoma. Among types of solar radiation, ultraviolet B (290-320 nm) radiation is highly mutagenic and carcinogenic in animal experiments compared to ultraviolet A (320-400 nm) radiation. Epidemiological studies s...
متن کاملassessment of the park- ang damage index for performance levels of rc moment resisting frames
چکیده هدف اصلی از طراحی لرزه ای تامین ایمنی جانی در هنگام وقوع زلزله و تعمیر پذیر بودن سازه خسارت دیده، پس از وقوع زلزله است. تجربه زلزله های اخیر نشان داده است که ساختمان های طراحی شده با آیین نامه های مبتنی بر نیرو از نظر محدود نمودن خسارت وارده بر سازه دقت لازم را ندارند. این امر سبب پیدایش نسل جدید آیین نامه های مبتنی بر عملکرد شده است. در این آیین نامه ها بر اساس تغییرشکل های غیرارتجاعی ...
15 صفحه اولErlotinib-induced skin inflammation is IL-1 mediated in KC-Tie2 mice and human skin organ culture
Nicole L. Ward1,*,$, Narasimharao Bhagathavula2,*, Andrew Johnston3,*, Sean M. Dawes1, Wen Fu1, Sylviane Lambert3, Michael K. Dame2, Roscoe L. Warner2, Johann E. Gudjonsson3, James Varani2, and James T. Elder3,4,$ 1Department of Dermatology, Case Western Reserve University, Cleveland, OH 2Department of Pathology, University of Michigan, Ann Arbor, MI 3Department of Dermatology, University of Mi...
متن کاملHuman skin: an independent peripheral endocrine organ.
The historical picture of the endocrine system as a set of discrete hormone-producing organs has been substituted by organs regarded as organized communities in which the cells emit, receive and coordinate molecular signals from established endocrine organs, other distant sources, their neighbors, and themselves. In this wide sense, the human skin and its tissues are targets as well as producer...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Expert Review of Dermatology
سال: 2012
ISSN: 1746-9872,1746-9880
DOI: 10.1586/edm.12.24